The William Pepperrell House is a historic house at 94 Pepperrell Road in Kittery Point, Maine. Built about 1682 and later enlarged and restyled, it was at the time of its construction the grandest house in what is now the state of Maine. It is notable as the birthplace and home of Sir William Pepperrell (1696–1759) a leading businessman of the period whose greatest claim to fame was leading the 1745 Siege of Louisbourg during King George's War. The house was listed on the National Register of Historic Places in 1973.